Basic Concepts of a Mendelian Randomization Approach
نویسندگان
چکیده
منابع مشابه
Mendelian Randomization Causal Analysis Adiposity as a cause of cardiovascular disease: a Mendelian randomization study
Background: Adiposity, as indicated by body mass index (BMI), has been associated with risk of cardiovascular diseases in epidemiological studies. We aimed to investigate if these associations are causal, using Mendelian randomization (MR) methods. Methods: The associations of BMI with cardiovascular outcomes [coronary heart disease (CHD), heart failure and ischaemic stroke], and associations o...
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The phrase "mendelian randomization" has become associated with the use of genetic polymorphisms to uncover causal relationships between phenotypic variables. The statistical methods useful in mendelian randomization are known as instrumental variable techniques. We present an approach to instrumental variable estimation that is useful in family data and is robust to the use of weak instruments...
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ژورنال
عنوان ژورنال: Cardiovascular Prevention and Pharmacotherapy
سال: 2020
ISSN: 2671-700X
DOI: 10.36011/cpp.2020.2.e3